Diacerin , Glucosamine & MSM

Diacerein, also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
MSM has been proven to have anti-inflammatory and antioxidant mechanisms in an in vitro study6 in which human neutrophils were artificially stimulated to produce oxidative compounds, including hydrogen peroxide, superoxide, and hypochlorous acid. After cell lines were treated with either DMSO or DMSO2, these free radical by-products were decreased.

Adverse effects are generally mild: itching, diarrhea, heartburn, nausea and vomiting.

Glucosamine is usually used in the treatment of osteoarthritis, although its efficacy is still in question.