| COMPOSITION | |
|---|---|
| DOXYLAMINE | 10MG |
| PYRIDOXINE | 10MG |
| FOLIC ACID | 2.5MG |
DOXYLAMINE, PYRIDOXINE & FOLIC ACID
FOLIVIB PLUS
| SPECIFICATION | |
|---|---|
| FORM | TABLET |
| PACKING | 10×10 |
| PACKING TYPE | BLISTER |
| MRP | 450 |
DESCRIPTION
Doxylamine
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]
Pyridoxine
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
SIDE EFFECTS
Doxylamine
Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
Pyridoxine
Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
INDICATION
Doxylamine
Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
Pyridoxine
For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.