| COMPOSITION | |
|---|---|
| DUTASTERIDE | 0.5MG |
| TAMULOSIN HYDROCHORIDE | 0.4MG |
DUTASTERIDE, TAMSULOSIN & HYDROCHLORIDE
URIVIB T
| SPECIFICATION | |||
|---|---|---|---|
| FORM | TABLET | ||
| PACKING | 10×10 | ||
| PACKING TYPE | ALU ALU | ||
| MRP | |||
DESCRIPTION
DUTASTERIDE
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group, but while dutasteride inhibits both isoforms of 5-alpha reductase, finasteride inhibits only one. Even so, a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH.
TAMSULOSIN & HYDROCHLORIDE
Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.
SIDE EFFECTS
DUTASTERIDE
For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for surgery.
Tamsulosin Hydrochloride
LD<sub>50</sub> = 650 mg/kg (in rats)
INDICATION
Tamsulosin Hydrochloride
Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream…etc.)