| COMPOSITION | |
|---|---|
| LEVONORGESTREL | 0.15MG |
| ETHINYLESTRADIOL | 0.03 |
LEVONORGESTREL, ETHINYLESTRADIOL
OVAVIB
| SPECIFICATION | |||
|---|---|---|---|
| FORM | TABLET | ||
| PACKING | 10×21 | ||
| PACKING TYPE | BLISTER | ||
| MRP | |||
DESCRIPTION
LEVONORGESTREL
A synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. It is usually supplied in a racemic mixture (Norgestrel, 6533-00-2). Only the levonorgestrel isomer is active. Levonorgestrel is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Triphasil, and Min-Ovral.
ETHINYL ESTRADIOL
A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives. Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
SIDE EFFECTS
ETHINYLESTRADIOL
Oral, mouse LD<sub>50</sub>: 1737 mg/kg. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.
LEVONORGESTREL
In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
INDICATION
LEVONORGESTREL
For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
ETHINYLESTRADIOL
For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.