| COMPOSITION | |
|---|---|
| TAMSSULOSIN | 0.4MG |
TAMSULOSIN
TAMLOVIB
| SPECIFICATION | |||
|---|---|---|---|
| FORM | TABLET | ||
| PACKING | 10×21 | ||
| PACKING TYPE | ALU ALU | ||
| MRP | |||
DESCRIPTION
TAMSULOSIN
Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.
SIDE EFFECTS
Tamsulosin
LD<sub>50</sub> = 650 mg/kg (in rats)
INDICATION
Tamsulosin
Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream…etc.)