Timolol Maleate

VIBOTIM EYE DROP

COMPOSITION
Timolol Maleate0.5%W/V
SPECIFICATION
FORMEYE DROP
PACKING 5ML
PACKING TYPE1’s
MRP49

DESCRIPTION

A beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor. [PubChem]

SIDE EFFECTS

LD50=1190 mg/kg (oral, mice), LD50=900 mg/kg (oral, rat). Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block.

INDICATION

In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.