Calcium Citrate Maleate , Vitamin D3 & Folic Acid

Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.

Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects. There are 2 main forms of vitamin D; vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol). These compounds need to undergo hydroxylation in order to be biologically active in the body. Since vitamin D can be synthesized in adequate amounts by most mammals exposed to sufficient sunlight, vitamin D acts as a hormone that acts on vitamin D receptors to regulate calcium in opposition to parathyroid hormone. Vitamin D plays an essential physiological role in maintaining calcium homeostasis and metabolism. There are several different vitamin D supplements that are given to treat or to prevent osteomalacia and rickets, or to meet the daily criteria of vitamin D consumption.

Folic Acid :A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Calcium citrate Constipation, Stomach ache, Loss of appetite, Feeling of sickness, Excessive thirst, Muscle weakness are possible side-effects that may occur in medicines that contain Calcium Citrate Malate / Vitamin D3. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

Folic Acid :IPR-MUS LD₅₀ 85 mg/kg,IVN-GPG LD₅₀ 120 mg/kg, IVN-MUS LD₅₀ 239 mg/kg, IVN-RAT LD₅₀ 500 mg/kg, IVN-RBT LD₅₀ 410 mg/kg.

Calcium citrate : Patients taking more than 4g of calcium a day are at risk of hypercalcemia and metabolic alkalosis [L811]. Chronic intake of calcium supplements is associated with adverse gastrointestinal symptoms such as constipation and flatulence [L811] [A19538].

Folic Acid :For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.