|ZINC PYRITHIONE (ZPTO)||1.0W/V|
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. It is a racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole with the chiral centers on the acetal ring.
Pyrithione zinc is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. In the crystalline state, it exists as a centrosymmetric dimer. Due to its fungistatic and bacteriostatic properties, pyrithione zinc is used as an active ingredient to treat dandruff and seborrheic dermatitis. It is commonly found in OTC antidandruff topical treatments such as shampoos. Other uses of pyrithione zinc include additive in outdoor paints and algaecide.
Hepatotoxicity, LD50=86 mg/kg (orally in rat)
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.